Freeze dryer has attracted market attention

The lyophilizer is also called a production lyophilizer, and its principle is a technical method of pre-freezing an aqueous article and then sublimating its moisture under vacuum to obtain a dried article. The freeze-dried articles are easy to preserve for a long period of time. After adding water, they can return to their pre-lyophilized state and maintain their original biochemical characteristics. For heat-sensitive substances such as antibiotics, vaccines, blood products, enzyme hormones and other biological products, freeze-drying technology can better show its superiority.

Lyophilizers play an irreplaceable role in food and pharmaceutical companies. The process includes dipping, air-cooling, direct-cooling, and vacuum-cooling. Among them, the soaking method has the fastest freezing speed, and the material is immersed in liquid nitrogen, liquid Freon, low temperature brine and other mediums for rapid freezing; the air cooling method is blowing low-temperature cold wind on the material, so that the material freezes within a specified time. The temperature; direct cooling method is to put the refrigerant or refrigerant placed in the evaporation tube, to absorb the heat of the material to achieve the purpose of cooling; vacuum cooling method is to use vacuum to make the moisture in the material to take away heat, cooling material to achieve cooling purposes.

According to experts, no matter what method is used, it should be ensured that the materials will freeze to a certain temperature within the specified time without being deformed. In order to ensure that the ice in the material is insolubilized and vaporized (sublimation) and the vapors are continuously removed to ensure the normal sublimation, the degree of vacuum in the tank must be lower than the saturated vapor pressure of ice at a certain temperature (below 610 pa).

The high-quality freezing process coupled with a powerful refrigeration system makes the freeze dryer a “darling” in the market. Small freeze dryers have more varieties of lyophilizers on the market, and users often have no choice when they choose. There are industry professionals to give users tricks: First, according to the characteristics of the material, choose the configuration of a small freeze dryer, is an ordinary type, ordinary multi-manifold type, or gland type, gland multi manifold type, safety tube type, T type . Then determine the pre-freezing temperature of the lyophilizer, if you are ready to pre-freeze in a low-temperature refrigerator can not be considered in determining whether it is necessary to configure -80 °C function (used for organic solution drying).

With the continuous deepening of research on freeze-drying technology, the market has also increased the requirements for freeze dryers. For example, how to ensure the quality of freeze-dried products, how to design more humane, more energy-efficient and efficient have become an important factor in market competition, drug machine Enterprises should seize the market demand and industry trends, and carry out the transformation and replacement of equipment in a timely manner.

People in the industry believe that due to the lyophilization process of the lyophilizer is more complex and the range of working conditions is narrow, the quality of the freeze-dried product will be reduced due to slight carelessness. Therefore, an automatic control system is required. The design of the lyophilization machine automatic control system requires simple operation, starting from the material into the button, quick-freeze vacuum sublimation drying one after the other, suggesting that the lyophilization is completed after the shutdown discharge. The relevant temperature and pressure control points should be carefully selected and reasonably controlled, and the associations of quick freezing, vacuum maintenance, and heating should be properly controlled, and the technological curves should be set for different materials. In recent years, the technology of automation technology has promoted the progress of freeze dryers. Modern freeze-drying equipment not only satisfies the requirements of various freeze-drying processes, but also can successfully use electronic computers to fully control the operation and control to freeze dryers. Bring great safety and convenience.

The author believes that the current development of China's biopharmaceutical industry is good, and policy support efforts continue to increase. Pharmaceutical companies are also focusing on product innovation, but also more stringent requirements for related pharmaceutical equipment. As a member of the lyophilization machine manufacturer, it must keep pace with the innovation of pharmaceutical companies, move the pulse market, improve the ability of technological innovation, create products that are more in line with the needs of the industry, and help China's pharmaceutical industry to take a higher level.

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