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Phil Bardin, director of healthy breathing and sleep medicine at Monash University, said that he and his colleagues tested 11 patients with moderate-to-severe asthma with vocal cord dysfunction during CT scans. They used a so-called "bronchoscope" to observe specific vocal cord tissue areas that were infused with small amounts of botulinum toxin. Most patients reported that their asthma symptoms improved significantly during the month after the injection of botulinum, and the CT scan also showed that their airway size was increased. Prof. Bardin said that the effect of botulinum bacteria usually lasts for two or three months. However, one of the side effects of the vocal cords is that patients report more softly than usual.
Professor Bardin said that a larger experiment was needed to confirm the findings of the study, but his team demonstrated that botulinum is feasible and safe in treating patients with severe vocal cord dysfunction.